GHK-Cu is a naturally occurring copper complex originally isolated from human plasma. This revolutionary skincare ingredient combines the regenerative properties of the GHK peptide with the biological activity of copper.

Human copper peptides exist naturally in our skin. As we age, GHK-Cu levels decrease by about 60% by age 60, correlating with visible signs of aging. GHK-Cu has been established as a key signaling molecule in various studies since its discovery in 1973.

Clinical studies have shown that GHK-Cu is safe at concentrations up to 2% in skincare formulations, with no significant irritation or sensitization in human patch testing. Research validates its efficacy through multiple pathways:

Tyrosine Kinase Inhibition

In controlled studies, GHK-Cu demonstrated modulation of tyrosine kinase activity by up to 27%, helping regulate cellular processes involved in skin aging.

Antioxidant Activity

Research shows GHK-Cu increases antioxidant enzyme activities, specifically superoxide dismutase by 47% and catalase by 69%. Studies also demonstrated a 41% reduction in free radical production under UVB stress.

Collagen Degradation

Clinical data shows GHK-Cu increases collagen synthesis by up to 70% in human fibroblasts, while simultaneously reducing MMP (Matrix Metalloproteinase) activity by approximately 33%. Studies indicate a 28% increase in skin thickness after 12 weeks of regular use.

Enzyme Inhibition

The copper peptide complex demonstrates significant inhibition of key aging-related enzymes: approximately 31% reduction in elastase activity and 47% reduction in collagenase activity at standard use concentrations.